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1

Computer-based courseware: a comparative review of the learner's experience

Mabey, Christopher, Topham, Paul, Roland Kaye, G.

Journal:

Accounting Education

Year:

1998

Language:

english

File:

PDF, 192 KB

english, 1998

2

Construction of a synthetic pathway for the production of 1,3-propanediol from glucose

Frazão, Cláudio J. R., Trichez, Débora, Serrano-Bataille, Hélène, Dagkesamanskaia, Adilia, Topham, Christopher M., Walther, Thomas, François, Jean Marie

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 1.92 MB

english, 2019

3

Airway gene expression correlates of RSV disease severity and microbiome composition in infants

Chu, Chin-Yi, Qiu, Xing, McCall, Matthew N, Wang, Lu, Corbett, Anthony, Holden-Wiltse, Jeanne, Slaunwhite, Christopher, Grier, Alex, Gill, Steven R, Pryhuber, Gloria S, Falsey, Ann R, Topham, David J,

Journal:

The Journal of Infectious Diseases

Year:

2020

File:

PDF, 1.16 MB

2020

4

The Kinetic Basis of a General Method for the Investigation of Active Site Content of Enzymes and Catalytic Antibodies: First-Order Behaviour under Single-turnover and Cycling Conditions

CHRISTOPHER M. TOPHAM, SHERAZ GUL, MARINA RESMINI, SANJIV SONKARIA, GERRARD GALLACHER, KEITH BROCKLEHURST

Journal:

Journal of Theoretical Biology

Year:

2000

Language:

english

File:

PDF, 321 KB

english, 2000

5

A generalized theoretical treatment of the kinetics of an enzyme-catalysed reaction in the presence of an unstable irreversible modifier

Christopher M. Topham

Journal:

Journal of Theoretical Biology

Year:

1990

Language:

english

File:

PDF, 1.17 MB

english, 1990

6

Ill-conditioning associated with the “end-point” method for the determination of kinetic parameters describing irreversible enzyme inactivation by an unstable inhibitor

Christopher M. Topham

Journal:

Journal of Theoretical Biology

Year:

1988

Language:

english

File:

PDF, 279 KB

english, 1988

7

Comparative modelling of major house dust mite allergen Der p I: structure validation using an extended environmental amino acid propensity table

Topham, Christopher M., Srinivasan, N., Thorpe, Christopher J., Overington, John P., Kalsheker, Noor A.

Journal:

Protein Engineering Design and Selection

Year:

1994

Language:

english

File:

PDF, 7.79 MB

english, 1994

8

Half-time analysis of the kinetics of irreversible enzyme inhibition by an unstable site-specific reagent

Christopher M. Topham

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1988

Language:

english

File:

PDF, 1.41 MB

english, 1988

9

Purification and characterization of an iron-binding protein from the blue crab Callinectes sapidus)

Christopher C. Landry, Richard W. Topham

Journal:

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry

Year:

1990

Language:

english

File:

PDF, 569 KB

english, 1990

10

Informal out-patient discussions with patients following surgery for large bowel cancer: are they beneficial?

MARY BROUGHTON, GAIL DOULTON, CLARE TOPHAM, CHRISTOPHER MARKS

Journal:

European Journal of Cancer Care

Year:

1995

Language:

english

File:

PDF, 469 KB

english, 1995

11

Informal out-patient discussions with patients following surgery for large bowel cancer: are they beneficial?

MARY BROUGHTON RGN, GAIL DOULTON RGN, CLARE TOPHAM FRCR, CHRISTOPHER MARKS FRCS

Journal:

European Journal of Cancer Care

Year:

1995

Language:

english

File:

PDF, 469 KB

english, 1995

12

Chemical modification of sheep-liver 6-phosphogluconate dehydrogenase by diethylpyrocarbonate : Evidence for an essential histidine residue

Christopher M. TOPHAM, Keith DALZIEL

Journal:

Year:

1986

Language:

english

File:

PDF, 880 KB

english, 1986

13

Kinetic studies of 6-phosphogluconate dehydrogenase from sheep liver

Christopher M. TOPHAM, Brian MATTHEWS, Keith DALZIEL

Journal:

Year:

1986

Language:

english

File:

PDF, 1.62 MB

english, 1986

14

Fragment Ranking in Modelling of Protein Structure: Conformationally Constrained Environmental Amino Acid Substitution Tables

Christopher M. Topham, Alasdair McLeod, Frank Eisenmenger, John P. Overington, Mark S. Johnson, Tom L. Blundell

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 1.48 MB

1993

15

Characterization of the Electrostatic Perturbation of a Catalytic Site (Cys)-S–/(His)-Im+H Ion-pair in One Type of Serine Proteinase Architecture by Kinetic and Computational Studies on Chemically Mutated Subtilisin Variants

Francisco J. Plou, Devanand Kowlessur, Paul G.J. Malthouse, Geoffrey W. Mellor, Michael J. Hartshorn, Surapong Pinitglang, Hasu Patel, Christopher M. Topham, Emrys W. Thomas, Chandra Verma, Keith Broc

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 1012 KB

english, 1996

16

The influence of helix morphology on co-operative polyamide backbone conformational flexibility in peptide nucleic acid complexes

Christopher M. Topham, Jeremy C. Smith

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 584 KB

english, 1999

17

Kinetic and Titration Methods for Determination of Active Site Contents of Enzyme and Catalytic Antibody Preparations

Keith Brocklehurst, Marina Resmini, Christopher M. Topham

Journal:

Year:

2001

Language:

english

File:

PDF, 133 KB

english, 2001

18

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

Jean-Christophe Marine, Catriona McKay, Demin Wang, David J Topham, Evan Parganas, Hideaki Nakajima, Hélène Pendeville, Hideo Yasukawa, Atsuo Sasaki, Akihiko Yoshimura, James N Ihle

Journal:

Year:

1999

Language:

english

File:

PDF, 626 KB

english, 1999

19

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

Evan Parganas, Demin Wang, Dimitrios Stravopodis, David J Topham, Jean-Christophe Marine, Stephan Teglund, Elio F Vanin, Sara Bodner, Oscar R Colamonici, Jan M van Deursen, Gerard Grosveld, James N Ih

Journal:

Year:

1998

Language:

english

File:

PDF, 436 KB

english, 1998

20

The nociceptin (ORL1) receptor: molecular cloning and functional architecture

Jean-Claude Meunier, Lionel Mouledous, Christopher M Topham

Journal:

Year:

2000

Language:

english

File:

PDF, 474 KB

english, 2000

21

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

Jean-Christophe Marine, David J Topham, Catriona McKay, Demin Wang, Evan Parganas, Dimitrios Stravopodis, Akihiko Yoshimura, James N Ihle

Journal:

Year:

1999

Language:

english

File:

PDF, 257 KB

english, 1999

22

Orientation Preferences of Backbone Secondary Amide Functional Groups in Peptide Nucleic Acid Complexes: Quantum Chemical Calculations Reveal an Intrinsic Preference of Cationic D-Amino Acid-Based Chiral PNA Analogues for the P-form

Topham, Christopher M., Smith, Jeremy C.

Journal:

Biophysical Journal

Year:

2007

Language:

english

File:

PDF, 814 KB

english, 2007

23

Adaptive Smith-Waterman residue match seeding for protein structural alignment

Topham, Christopher M., Rouquier, Mickaël, Tarrat, Nathalie, André, Isabelle

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2013

Language:

english

File:

PDF, 1.61 MB

english, 2013

24

Dissociation and reconstitution of human ferroxidase II

Lykins, Lee F., Akey, Christopher W., Christian, Ellen G., Duval, George E., Topham, Richard W.

Journal:

Year:

1977

Language:

english

File:

PDF, 1.50 MB

english, 1977

25

[IEEE 2013 International Conference on Embedded Computer Systems: Architectures, Modeling, and Simulation (SAMOS XIII) - Agios konstantinos, Samos Island, Greece (2013.07.15-2013.07.18)] 2013 International Conference on Embedded Computer Systems: Architectures, Modeling, and Simulation (SAMOS) - High speed cycle approximate simulation for cache-incoherent MPSoCs

Thompson, Christopher, Gould, Miles, Topham, Nigel

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

26

[IEEE 2011 International Conference on Embedded Computer Systems: Architectures, Modeling, and Simulation (SAMOS XI) - Samos, Greece (2011.07.18-2011.07.21)] 2011 International Conference on Embedded Computer Systems: Architectures, Modeling and Simulation - Scalable multi-core simulation using parallel dynamic binary translation

Almer, Oscar, Bohm, Igor, von Koch, Tobias Edler, Franke, Bjorn, Kyle, Stephen, Seeker, Volker, Thompson, Christopher, Topham, Nigel

Year:

2011

Language:

english

File:

PDF, 3.00 MB

english, 2011

27

Advanced Medical Radiation Technologist Practice and the Canadian Association of Medical Radiation Technologists: History and Perspective

Topham, Christopher

Journal:

Journal of Medical Imaging and Radiation Sciences

Year:

2014

Language:

english

File:

PDF, 156 KB

english, 2014

28

Probing impact of active site residue mutations on stability and activity of Neisseria polysaccharea amylosucrase

Daudé, David, Topham, Christopher M., Remaud-Siméon, Magali, André, Isabelle

Journal:

Protein Science

Year:

2013

Language:

english

File:

PDF, 999 KB

english, 2013

29

Tri-peptide reference structures for the calculation of relative solvent accessible surface area in protein amino acid residues

Topham, Christopher M., Smith, Jeremy C.

Journal:

Computational Biology and Chemistry

Year:

2015

Language:

english

File:

PDF, 821 KB

english, 2015

30

Book reviews

Unger, Jonathan, Dean, Genevieve C., Howe, Christopher, Topham, Neville, Ingham, Barbara, Thorp, Rosemary, Cramp, A. B., O'Brien, Donal Cruise, Crump, Thomas, Beals, J. J., Pratt, Brian, O'Brien, Phil

Journal:

Journal of Development Studies

Year:

1974

Language:

english

File:

PDF, 2.29 MB

english, 1974

31

The expression and prognostic significance of HER-2 in colorectal cancer and its relationship with clinicopathological parameters

Essapen, Sharadah, Thomas, Hilary, Green, Margaret, De Vries, Corrine, Cook, Martin, Marks, Christopher, Topham, Clare, Modjtahedi, Helmout

Journal:

International Journal of Oncology

Year:

2004

Language:

english

File:

PDF, 2.00 MB

english, 2004

32

Coexpression, prognostic significance and predictive value of EGFR, EGFRvIII and phosphorylated EGFR in colorectal cancer

Cunningham, Matthew, Essapen, Sharadah, Thomas, Hilary, Green, Margaret, Lovell, David, Topham, Clare, Marks, Christopher, Modjtahedi, Helmout

Journal:

International Journal of Oncology

Year:

2005

Language:

english

File:

PDF, 1.94 MB

english, 2005

33

[Society of Petroleum Engineers SPE/EAGE European Unconventional Resources Conference and Exhibition - Vienna, Austria (2012-03-20)] SPE/EAGE European Unconventional Resources Conference and Exhibition - The Challenges of Shale Gas Exploration and Appraisal in Europe and North Africa

Burns, Christopher, Topham, Adrian Paul, Lakani, Ramin

Language:

english

File:

PDF, 3.67 MB

english

34

An Atomistic Statistical Effective Energy Function for Computational Protein Design

Topham, Christopher Michael, Barbe, Sophie, André, Isabelle

Journal:

Journal of Chemical Theory and Computation

Year:

2016

Language:

english

File:

PDF, 1.42 MB

english, 2016

35

Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection

DeDiego, Marta L., Anderson, Christopher S., Yang, Hongmei, Holden-Wiltse, Jeanne, Fitzgerald, Theresa, Treanor, John. J., Topham, David J.

Journal:

Year:

2016

Language:

english

File:

PDF, 565 KB

english, 2016

36

A general kinetic approach to investigation of active-site availability in macromolecular catalysts

RESMINI, Marina, GUL, Sheraz, CARTER, Steve, SONKARIA, Sanjiv, TOPHAM, Christopher M., GALLACHER, Gerrard, BROCKLEHURST, Keith

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 198 KB

english, 2000

37

A general kinetic approach to investigation of active-site availability in macromolecular catalysts

RESMINI, Marina, GUL, Sheraz, CARTER, Steve, SONKARIA, Sanjiv, TOPHAM, Christopher M., GALLACHER, Gerrard, BROCKLEHURST, Keith

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 198 KB

english, 2000

38

Three-dimensional structure of a B-type chymopapain

TOPHAM, CHRISTOPHER M., OVERINGTON, JOHN, O'DRISCOLL, MAIREAD, SALIH, ERDJAN, THOMAS, MARK, THOMAS, EMRYS W., BROCKLEHURST, KEITH

Journal:

Biochemical Society Transactions

Year:

1990

Language:

english

File:

PDF, 256 KB

english, 1990

39

Polyclonal-antibody-catalysed hydrolysis of an aryl nitrophenyl carbonate

GALLACHER, GERARD, JACKSON, CAROLINE S., TOPHAM, CHRISTOPHER M., SEARCEY, MARK, TURNER, BENJAMIN C., BADMAN, GEOFFREY T., BROCKLEHURST, KEITH

Journal:

Biochemical Society Transactions

Year:

1990

Language:

english

File:

PDF, 218 KB

english, 1990

40

Investigation of mechanistic consequences of natural structural variation within the cysteine proteinases by knowledge-based modelling and kinetic methods

TOPHAM, CHRISTOPHER M., OVERINGTON, JOHN, KOWLESSUR, DEVENAND, THOMAS, MARK, THOMAS, EMRYS W., BROCKLEHURST, KEITH

Journal:

Biochemical Society Transactions

Year:

1990

Language:

english

File:

PDF, 207 KB

english, 1990

41

Three-dimensional structure and thiol reactivity characteristics of chymopapain M (papaya proteinase IV)

TOPHAM, CHRISTOPHER M., OVERINGTON, JOHN, THOMAS, MARK, KOWLESSUR, DEVANAND, THOMAS, EMRYS W., BROCKLEHURST, KEITH

Journal:

Biochemical Society Transactions

Year:

1990

Language:

english

File:

PDF, 250 KB

english, 1990

42

A general kinetic equation for multihydronic state reactions and rapid procedures for parameter evaluation

BROCKLEHURST, SIMON M., TOPHAM, CHRISTOPHER M., BROCKLEHURST, KEITH

Journal:

Biochemical Society Transactions

Year:

1990

Language:

english

File:

PDF, 274 KB

english, 1990

43

ACTINIDIN AND CHYMOPAPAIN B PROVIDE VARIATION IN THE COMMON ELECTROSTATIC ENVIRONMENT OF GLU50 IN PAPAIN AND CARICAIN

REID, JAMES D., PINITGLANG, SURAPONG, TOPHAM, CHRISTOPHER M., VERMA, CHANDRA, THOMAS, EMRYS W., BROCKLEHURST, KEITH

Journal:

Biochemical Society Transactions

Year:

1997

Language:

english

File:

PDF, 143 KB

english, 1997

44

Patient-Centered Care

Smith, Katherine, Topham, Christopher

Journal:

Journal of Medical Imaging and Radiation Sciences

Year:

2016

Language:

english

File:

PDF, 236 KB

english, 2016

45

Coexpression of the IGF-IR, EGFR and HER-2 is common in colorectal cancer patients

Cunningham, Matthew, Essapen, Sharadah, Thomas, Hilary, Green, Margaret, Lovell, David, Topham, Clare, Marks, Christopher, Modjtahedi, Helmout

Journal:

International Journal of Oncology

Year:

2006

Language:

english

File:

PDF, 315 KB

english, 2006

46

Anti-inflammatory treatment improves high-density lipoprotein function in rheumatoid arthritis

O'Neill, Francis, Charakida, Marietta, Topham, Eric, McLoughlin, Eve, Patel, Neha, Sutill, Emma, Kay, Christopher W M, D'Aiuto, Francesco, Landmesser, Ulf, Taylor, Peter C, Deanfield, John

Journal:

Year:

2017

Language:

english

File:

PDF, 656 KB

english, 2017

47

A practical approach to Events Medicine provision

Smith, Susan P, Cosgrove, Joseph F, Driscoll, Peter J, Smith, Andrew, Butler, John, Goode, Peter, Waldmann, Carl, Vallis, Christopher J, Topham, Fiona, Mythen, Michael (Monty)

Journal:

Emergency Medicine Journal

Year:

2016

Language:

english

File:

PDF, 383 KB

english, 2016

48

Natural H3N2 influenza A Infection in Humans Expands Memory B Cells Specific for the Hemagglutinin Stalk Domain

Tesini, Brenda, Halliley, Jessica, Ellebedy, Ali, Kanagaiah, Preshetha, Anderson, Christopher, Dediego, Marta, Wang, Jiong, Zand, Martin, Ahmed, Rafi, Krammer, Florian, Treanor, John J., Topham, David

Journal:

Open Forum Infectious Diseases

Year:

2016

Language:

english

File:

PDF, 34 KB

english, 2016

49

Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid

Walther, Thomas, Topham, Christopher M., Irague, Romain, Auriol, Clément, Baylac, Audrey, Cordier, Hélène, Dressaire, Clémentine, Lozano-Huguet, Luce, Tarrat, Nathalie, Martineau, Nelly, Stodel, Mario

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 1.05 MB

english, 2017

50

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain

Anderson, Christopher S., Ortega, Sandra, Chaves, Francisco A., Clark, Amelia M., Yang, Hongmei, Topham, David J., DeDiego, Marta L.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.74 MB

english, 2017